If we're talking about diseases they were worse off, but if we're talking about relationships, the British had a terrible relationship with the natives and treated the natives as obstacles. but the French had trading relationships with the natives and became allies.
The answer is obviously B. Th Spanish conquistadors were outnumbered 8 to 1. Their best weapons were the diseases they brought with them. In Europe decades before, Europeans lived in closely tight villages making disease rampant and frequent. This mad them have strong immune systems while the native Americans always lived far apart because north and South America are big, making less disease meaning that they could build up a strong immune system.
I would think B
I would get a second source on this though