Question

The scientific method depends on 1. reproducible results or 2. clearly stated laws of nature or 3. accurate initial predictions or 4. fact-based hypotheses or 4. communication of findings

Answer 1

The scientific method definitely relies on reproducible results - this is definitely the correct answer.

The hypotheses do not need to be based on fact - they will, after all still be tested, and only the results of the testing has to be based on a fact.