Pretty sure it was new disease, since Columbus brought small pox, measles, and the influenza with him to America. Hope this helps!
The colonists called it the French and Indian War, and it permanently shifted the global balance of power. By the mid-18th century, both the British and French wanted to extend their North American colonies into the land west of the Appalachian Mountains, known then as the Ohio Territory.
The answer is technically false. All of these years are within the fifteenth century, except for 1401. The fifteenth century a.d. lasted from 1401 - 1500.
The Portuguese and the Spanish.
