Question

a. Discuss one situation when you would use wormbase first? b. Discuss one situation when you would use OMIM first? c. Discuss one situation when you would use BLAST first? Disease: Bipolar Disorder 1. In order to find the genes influencing this disease or condition, which database would you use first? We used: NCIB, OMIM, Wormbase, BLAST. 2. Approximately how many genes (or DNA elements) are involved in this disease or condition? Explain how you came up with this number 3. Provide the genetic symbol of one of the protein-coding gene involved in this disease or condition. Explain how you know this gene is a protein-coding gene. 4. What is the cytogenetic location of this gene in Question 3? Explain what this location means. 5.What is the function of the protein coded by this gene in question 3? 6. All human diseases and traits are polygenic. Explain what "polygenic" means in this context. 7. Explain how you could find out if C. elegans has a protein similar to the one in Quesion 5? If you know the location or the OMIM# of Bipolar Disorder I can figure out the all the questions. I can't find the Bipolar Disorder OMIM and also correct for wormbase.

Answer 1

protein-coding gene

The genetic code is stored in the DNA of a cell. it is copied during the process of replication. An enzyme called helicase unwinds the double strand helix of DNA by breaking the hydrogen bonds that hold the two strands together, thus separating forming  what is called replication fork. Next the enzyme DNA polymerase uses the single strands as a template and makes  a new DNA strand by copying the template.