The reason for Ohio population grew that time was because the state disallowed slavery, it was also open to trade. It became an industrial state and also became an area for Native Americans to live. The place was an active area for living and family raising.
Answer:
C. European diseases killed many people.
Explanation:
The Natives were not immune to diseases that the outsiders brought in to their country, which led to them dying in large amount of numbers.
If you're referring to the Civil War era, in the years leading up to the war, once such compromise could have been that slavery could continue to exist where it was, but not spread to other states.