A. Kidney
It is one of the major organs
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
C) production of sperm and eggs
Explanation:
Sperms and eggs are the male and female gametes respectively. Formation of sperms and egg cells require meiotic cell division. Meiosis in sperm mother cells and egg mother cells reduces the chromosome number of half in the sperms and eggs. Meiosis also adds new gene combinations in these gametes by the process of crossing over.
Mitosis cannot reduce the chromosome number to half in the sperms and eggs. Absence of crossing over in mitosis leads to the formation of genetically identical progeny cells from mitosis.
Hence, mitosis can not form sperms and egg cells. If it does, the sperms and egg cells would not have genetic variations and there would be doubling of chromosome number with each round of sexual reproduction.
Your answer would be C i believe
the cholera outbreak was a pandemic because it spread through 3 continents
The smaller a population, the greater the potential effect of genetic drift on gene frequencies.
Genetic drift is an evolutionary term which refers to the random changes in a population's allele frequencies. These changes happen by chance due to the random selection of alleles from the genetic pool in each generation. Genetic drift can lead to either loss of some alleles or the fixation of others (100% frequency). The effect of genetic drift is stronger in smaller populations. This is because, the larger the population, the larger the sample size and the slower the result of genetic drift.
