Answer:
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Answer:
A mutation in Ras protein which will cause hyperactivity will eventually lead to cancer.
Explanation:
Ras protein was first discovered in Rous sarcoma virus (RSV) and it is a proto-oncogene product. In normal conditions, it plays an important role in cellular signalling but in case of gain of function/hyperactivity it gets converted into cellular oncogene. In several types of cancers a point mutation has been reported in Ras protein.
Just like G protein, it is also a GTPase switch protein but unlike G protein which is trimeric, it is monomeric. In the plasma membrane, it is attached with the help of lipids like prenyl or palmitoyl groups. During signal transduction pathway when it gets activated, it downstream activates MAPK pathway and causes gene expression but when it gets hyperactivated it causes over expression of genes leading to cancer.
Answer:
Genetic drift
Explanation:
Genetic drift is defined as the random change in allelic frequencies from one generation to the other.
Genetic drift is an evolutionary mechanism in which the allelic frequencies in a population change through many generations. Its effects are harder in a small-sized population, meaning that this effect is inversely proportional to the population size. Genetic drift results in some alleles loss, even those that are beneficial for the population, and the fixation of some other alleles by an increase in their frequencies. The final consequence is to <u>randomly</u> fixate one of the alleles. Low-frequency alleles are the most likely to be lost. Genetic drift results in a loss of genetic variability within a population.
Genetic drift has important effects on a population when this last one reduces its size dramatically because of a disaster -bottleneck effect- or because of a population split -founder effect-.
