Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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A physical change occur when objects or substances undergo a change that does not change in which the composition of a substance changes or one or more substances combine or break up from new substances.
Answer: Those which can adapt and withstand the high acidity levels of water.
The pond slowly becomes more acidic due to release of chemicals from a nearby factory. The chemicals released are acidic and toxic which will cause biomagnification in the pond water. Those organisms which can withstand the high acidic pH of water will survive. Others which can undergo adaptations can also survive.
The allele for dwarfism - D its dominant
Recessive allele -d
If the person has heterozygous alleles -Dd the person will have achrondroplastic dwarfism
However if the person if homozygous for the allele DD it’s Lethal and person can’t survive
If both parents are Dd
Dd X. Dd
Offspring DD Dd Dd dd
Probability of children who survive with the trait have the genotype Dd
Probability - 1/4 + 1/4
Probability of having surviving children with the trait -1/2 -0.5
The function of the limb is to help them get around and move. They might be similar in the way they’re structured? I don’t have a picture so I can’t tell. And you can assume that at one point these four animals all shared a common ancestor. Hope I helped!
