Coya Cusirimay (floruit 1493), was a princess and queen consort, Coya, of the Inca Empire by marriage to her brother, the Sapa Inca Huayna Capac (r 1493-1527). She was said to be responsible for the relief and well being of her people after natural disasters struck. The Spaniards led to the decline of the Inca civilization. The Spaniards took Atahualpa (ruler at the time,) hostage and killed his brother Huascar.
A region is a section of a country or the world with similar characteristics, and doesn't have to have a formal boundary.
Therefore, the Middle East is the best example of a region.
