The brain it creates a false sense of well being and energy a person will tend to push their body to the limit than it’s meant to go it can create a physical and mental breakdown after the effects of the drugs wear off it also decreases natural feelings of hunger they can experience extreme weight loss due to this also it disturbs your sleeping patterns so this has a lot to do with the brain because it controls all the things I’ve explained
Mosunetuzumab is a T-cell reliant bispecific antibody that binds to CD3 and CD20 to trigger T-cell mediated B-cell death.
However, cytokine release syndrome, which has the potential to limit dose and efficacy, can result from powerful immune stimulation with T-cell focused treatments.
We created a novel mechanistic model of immune and antitumor responses to the T-cell bispecifics (mosunetuzumab and blinatumomab), taking into account the dynamics of B- and T-lymphocytes in circulation, lymphoid tissues, and tumors, in order to better understand the mechanisms underlying safety and efficacy as well as to explore safety mitigation strategies.
Using mosunetuzumab nonclinical and blinatumomab clinical data, the model was created and validated. The initial step-fractionated dose was projected to minimize systemic T-cell activation and cytokine release without impairing tumour response.
Simulations described the mechanisms underlying the observed cell and cytokine (IL6) dynamics. The Phase I clinical study for mosunetuzumab was changed to a step-fractionated treatment schedule as a result of these findings, allowing for the safer administration of greater dosages.
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Answer:
Hematopoietic stem cells
Explanation:
These hematopoietic stem cells gives rise to the other blood cells in the bone marrow and the process is known as hematopoiesis. It occurs in the red bone marrow.
Bone marrow is the place where new blood cells are produced. It is the tissue comprising center of large bones and contains two types of stem cells: hematopoietic and stromal.
Answer: D(nucleoid region)
Explanation:
In the diagram below the irregular shaped, supercoiled region, without a membrane, labelled D, surrounded by the cytoplasm of the cell is the nucleiod region that contains the main DNA in bacterial.
The nucleoid region in the prokaryotic cell contains the main DNA material. The nucleoid which means nucleus-like contains the main genetic material in prokaryotic cell, some satellite DNA are found in plasmid is other parts of the cell. Unlike the nucleus of eukaryotic cells the nucleiod lacks a cell membrane. The nucleiod has an irregular shape, and has a circular chromosome.
