Fructose-1,6-bisphosphate is a feedforward <u>allosteric</u> activator of liver pyruvate kinase.
<h3>What is the role of fructose 1/6-Bisphosphate?</h3>
A crucial enzyme in gluconeogenesis is fructose 1,6-bisphosphatase (FBPase). It is a possible target for drugs used to treat type II diabetes. Additionally, the protein is linked to a rare genetic metabolic disorder, and certain cancer cells lack the activity of the enzyme FBPase, which encourages glycolysis and aids in the Warburg effect.
The following reaction is catalyzed by FBPase. The enzyme is controlled allosterically by several small molecules, including AMP and fructose-2,6-phosphate, which are negative regulators, and ATP, which is a positive regulator. Pyruvate kinase activity is activated when FBP attaches to the allosteric binding site on domain C of the enzyme. This conformational shift is brought on by a change in the enzyme's structure.
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Macromolecules are a set collection of polymers that composes most of the organic substances specifically in the organelles of cells. Thus, these organelles use lipids and proteins in doing cellular activity and keeps them functioning. Observe nitrogen and carbon, these two entities are called elements that are composed of atoms. Elements are the basic composition of a substance. Going back, examples of molecules could be nucleic tides, polypeptides, RNA, protein, lipids and etc. <span>
Protein
Carbohydrates
Lipids
Nucleic acids</span>
Answer:Density-independent factors, such as weather and climate, exert their influences on population size regardless of the population's density. In contrast, the effects of density-dependent factors intensify as the population increases in size. For example, some diseases spread faster in populations where individuals live.
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