Answer:
Option 3, Chromatids remain attached to one another until anaphase
Explanation:
Centromere lies at the center, end or other points of the chromosome and joins the two sister chromatids. During cell division, the spindle fibers attaches at the centromere and detaches the chromosomes during the anaphase of the cell division to ensure that each daughter cell gets equal number of chromosomes at the end of mitosis. Centromere plays an essential role in the separation of chromosomes.
Hence, option 3 is correct
Muscle fatigue is defined as a decrease in maximal force or power production in response to contractile activity. It can originate at different levels of the motor pathway and is usually divided into central and peripheral components. Peripheral fatigue is produced by changes at or distal to the neuromuscular junction.