Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
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Answer:
The IP stands for intellectual property. And the information ethics related to the IP are the transaction privacy, piracy and the privacy for the ease and giveaways, investigation, namelessness. The trade details must be kept private, and not disclosed to anybody, and the piracy is never allowed. Also, the privacy of all sorts must be ensured for ease and giveaways, surveillance, and confidentiality.
Explanation:
Please check the answer section.
Answer:
Transistors, vacuum tubes, integrated circuits, personal computers, microprocessors.
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These are the computer components in order from oldest to newest
Answer:
total=0
pet=input("what pet do you have? ")
while pet!= "rock":
total=total+1
print("you have a "+pet+" with a total of "+ str(total)+ " pet(s)")
pet=input("What pet do you have? ")
Explanation: Just copy and paste above again just copy and paste this will get you a 100 percent i made another account just to give yall edhesive answers if yall need help with any edhesive just comment below
The correct answer copyright
