Both
It explains: the slowdown
The magic shoes from the relative location of geography
After Macbeth kills King Duncan, his mental health begins to deteriorate. He tells us in this quote that after Duncan's murder, he is outside of the nourishing effects of sleep. By the time that Macbeth arranges for the murders of Banquo and Fleance and then Macduff's family, he has lost all of the comforts that humanity needs to survive.
The ability to sleep, eat, peace of mind, the company of friends and loved ones.
" Still it cried,'sleep no more', to all the house: 'Glamis hath murder'd sleep, and therefore Cawdor
Shall sleep no more, Macbeth shall sleep no more!
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