Question

Assume that for a given gene a mutation creates an allele that functions as a dominant negative. The gene codes for a protein that forms a tetramer (4) within the cell. If at least one of the subunits has the mutant structure the entire protein is inactivated. For a heterozygous individual, what percent of the tretramers present in the cell will be inactive?

Answer 1

Answer: 100%

Explanation:

if the mutation presents autosomal dominant inheritance, each affected individual will show 100% alteration in the protein, thus , being dominant, it is considered that the disease pattern will predominate even if it has genes that do not express it since these will be recessive and canceled by the dominant ones.