Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.
Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.
Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.
Learn more about mutations here : brainly.com/question/17031191
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The deoxygenated blood leave the right ventricle via pulmonary artery to the and is taken to the both right and left lung. That is the deoxygenated blood is taken to alveolar capillaries of the lung . As blood flows through the alveolar capillaries it is oxygenated as carbon dioxide leaves.
Answer:
This is complex
Explanation:
I recommend asking teacher for help and please don't ever my answers
The combination of citrus food in the diet may help Jared in creasing the absorption of iron by his intestine. The fruits and vegetables rich in Vitamin C and the Ascorbic acid such as lemon, oranges etc., may be used. Further, beta-carotene rich sources like carrots, apricots, beans, spinach also will also help him.