The spleen plays an important role in the immune system, therefore when the spleen is no longer present the immune system weakens and can cause the affected to become more susceptible to illness/infection. Furthermore, the affects individual will have a harder time fighting the illness/infection than someone with a full immune system.
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My guess is A, but I don't know for sure.
They are often targets because they don't fight back, they often provoke their aggressor.
