Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Segregation of alleles happens when the pair of alleles of each parent separate and only one allele passes from each parent on to an offspring. So if you had heterozygous tall plants and mated them (Tt x Tt), they would each separate into T and t, allowing each offspring to get either a T or a t from each parent. The possible genotypes would be TT, Tt and tt.
The correct answer should be: Bromide
<u>Definition:</u>
The sex hormone and endogenous steroid present in human and other species ' menstrual cycle, pregnancy, and embryogenesis are known as "Progesterone" while the primary sex hormone in females responsible for the development and control of the female reproductive system and for the characteristics of secondary sex is termed as "Estrogen" or "oestrogen".
<u>Progesterone Effects:</u>
- Progesterone has a variety of physiological effects which are exacerbated when estrogens are present for an instance in breast tissue, where estrogens permits progesterone to mediate lobuloalveolar development.
- Progesterone has main effects on human sperm by non-genomic signals, as they move through the female tract before fertilization.
- Progesterone is called "hormone of pregnancy" as transform the endometrium to its secretory stage for uterine implantation, decrease the maternal immune response to permit for the acceptance of the pregnancy during implantation and gestation, prevent preterm labor, inhibits lactation during pregnancy etc.
<u>Estrogen Effects:</u>
- Effects structure of human and categorize them as male and female, while females have three kind of estrogen: Estrone (weak and found in women after menopause), Estradiol (strong and it is steroid produced by ovaries ) and Estriol (weakest and waste product after body produces estradiol).
- It effects ovaries, vagina, Fallopian tube, uterus, cervix and mammary glands.
- It triggers the release of an egg due to high level during halfway of cycle but decreases after ovulation.
<u>Similarities between progesterone and estrogen: </u>
Progesterone and estrogen as such do not have similar function but work with coordination as both are need for menstrual cycle functioning and regulation. Estrogens usually travel in fluids through the bloodstream, communicate with cells in the body's various tissues, and provide a message or guidance while progesterone helps to balance pregnancy period and to implant an egg in uterus.
