Monogenetic disorders<span> are </span>caused<span> by a mutation in a single </span>gene. The mutationmay<span> be present on one or both chromosomes (one chromosome </span>inherited<span> from each parent). Examples of monogenic </span>disorders<span> are: sickle cell </span>disease<span>, cystic fibrosis, polycystic kidney </span>disease<span>, and Tay-Sachs </span>disease<span>.</span>