Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
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The first responsibility of the surgeon is notify the surgeon and go over the preoperative skin antiseptic choice.
Preoperative Skin- An excellent way to reduce surgery site infections is preoperative skin preparation (SSI). The two most often used antiseptics are povidone iodine (PV-I) and alcoholic chlorhexidine (CHG). Their effectiveness in lowering the normal bacterial skin flora after clean orthopedic surgery is the focus of this meta-analysis.
Antiseptic- An antiseptic is a substance that inhibits or stops the development of microorganisms on the body's outside surfaces, hence assisting in the prevention of illnesses.
Microorganism- A living thing that can only be observed under a microscope. Protozoa, algae, fungus, and bacteria are all examples of microorganisms.
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That right there is a line graph
I would say that answer choice C is the best out of this selection. Carbon is the main element in organic compounds, and organic compounds just so happen to make up the cells that carry out life processes for all living things. Hope this helps.
I think carbon dioxide then sugars
