The united states faced a number of political, economic, and social challenges after civil war.
De Soto's travels through Georgia left a bad taste between Europeans and native Americans. He was known to use harsh methods to get the cooperation of the native Americans in the area. Chief kingdoms that were once powerful slowly dissolved because de Soto brought with him diseases that native Americans were not immuned to. These diseases slowly killed de Soto's men and also the natives in Georgia.
The crops were all destroyed and long gone. The south had battles on many fields that once grew various types of crops. Men went missing who once tended the fields for the crops to go. Many of them ended up injured or even worse, death. Plantations were left abanded and destroyed. Transportation was gone. Railroad lines had been pulled out or torn apart to prevent the south from moving supplies. Even walking to find a way out was very dangerous for anybody.