Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
It has happened to me before. i think it’s just because someone is already typing an answer maybe ♀️ or try restarting the app and get back on it. might be jus a glitch from the app but either way hope you get it fixed :)
there are many differences, but the most prominent are that they have different apis (aplication programing interface) and different architecture
also mobile apps tend to use less system resources and are more regulated by services like the google play store, opposed to the fairly unregulated uwp platform used by most windows machines.
Answer:
a. True
Explanation:
The statement that a pen testing method or penetration test in which a tester who has a means of entry to an application behind its firewall imitates an attack that could be caused by a malicious insider.
A penetration test, which is also refer to as a pen test, pentest or ethical hacking, is an approved simulated cyberattack done on a computer system, performed in order to evaluate the security of the system. The test is carried out to identify both weaknesses or vulnerabilities including the potential for unauthorized parties to penetrate to the system's features and data.
The main purpose of performing this test is to identify any vulnerability in a system's defenses which attackers may take advantage of.
