Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes

1 answer:

8 0

<span>Canagliflozin is a recently discovered drug that is used in the treatment of type 2 diabetes, by inhibiting SGLT2 transporters in kidneys that reabsorb glucose from the urine.
EFFICACY:
Cohort studies were made to compare canagliflozin to other molecules (glimepiride and sitagliptin) by evaluating the life quality, weight and </span>HbA1c (glycated hemoglobin) for 52 weeks. it was found that canagliflozin has a better efficacity and a better effective cost ratio.

SIDE EFFECTS:
The most frequent side effects are constipation, thirstiness, nausea, and headache.
Due to its mechanism of action, a high glucosuria can be found also.
Severe complications can occur, like euglycemic ketoacidosis. This drug has a high amputation and risk (like other SGLT2 inhibitors) and a high fracture risk (due to the diminution of the mineralization of the bones).

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