The changes that occur in body size, proportions, and skeletal maturity during the middle childhood include; Bones continues to strengthen and broaden, permanent teeth replace the primary teeth, normally a third of school age children suffer from malocclusions, making braces common by the end of elementary school. Additionally, the children's growth is slow and regular though large individual and ethics variations exists in the physical growth. <span />
In our bodies the hormones and other regulators that are present usually operate in small quantities that range from pico to microgram/ml of blood and this level of hormone and other regulators is referred to as the physiological level.
when treatments are given then it may lead to the production of these hormones or regulators that may exceed the physiological levels, and the levels may increase up to milligram range.
Such treatments levels that lead to the excess production fo circulating levels that surpass the natural or optimal levels are termed as pharmacological doses.
