it better to be free because if you are safe there are restrictions but if you are free there aren't
Spent is the most negative connotation.
Explanation:
Fatigued is to feel exauhsted.
Weary is lack of sleep, tiredness.
Tired is just a minimal drousy feeling.
And spent is as if your energy was all used up, consumed.
I have never seen him so irate.
Hope this helps.