Answer:Smallpox and vaccination are intimately connected. Edward Jenner developed the first vaccine to prevent smallpox infections, and this success led to the global eradication of smallpox and the development of many more life-saving vaccines.
Explanation:
It's a close run between all of the above and C. If I would have to choose, I'd say C, since executing ALL the Spanish seems a bit extreme.<span />
The rivers are the seine, rhone, and loire