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The Trex-Binding Factor in Muscle Creatine Kinase Enhancer has been identified and described below.
The Muscle Creatine Kinase Enhancer contains a positive control site called Transcriptional Regulatory Element X (Trex). The Trex site is critical for MCK expression in skeletal and cardiac muscle, according to research using transgenic animals and cell culture. Quantitative proteomics was used to identify the Trex-binding factor (TrexBF) as Six
a homeodomain transcription factor of the Six/sine oculi's family, from a background of about
copurifying proteins, following selective enrichment for TrexBF using magnetic beads coupled to oligonucleotides containing either wild-type or mutant Trex sites. We showed that Six4 is TrexBF in mouse skeletal myocytes and embryonic day 10 chick skeletal and cardiac muscle, but Six
is the primary TrexBF in adult mouse heart, using gel shift assays and Six-specific antisera. Six
transactivates in co transfection investigations.
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The similarities in the structure of the three species is due to their sharing a common ancestor while the differences is due to adaptation.
<h3>What is divergent evolution?</h3>
Divergent evolution is evolution where individuals who shared a common ancient ancestor process to have differing structures due to differences in their habitats.
All three species that Flor observed having similar structures is because they had a common ancestor.
The species had differences because they evolved to adapt to their different environments.
Wall geckos and Pacific gulls have temporal holes in their skulls as adaptations to their habitat.
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