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postnew [5]
3 years ago
15

The large opening at the base of the skull through which the spinal cord passes is an important clue to evolutionary relationshi

ps. it is called the
Biology
1 answer:
liraira [26]3 years ago
3 0

Answer:It is called The Foramen Magnum

Explanation: It is a large oval opening linking the Spinal cord and the Brain

Hope this helps : )

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B

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3 years ago
Based on the definitions of pharmacophore and privileged structure, outline essential structural features a 1,4-dihyrdopyridine
stiv31 [10]

Answer:

Explanation:

Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.

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1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.

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antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .

Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.

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