Answer and Explanation:
Ergotamine has been used for over 50 years and was the first specific drug to treat migraine attacks. Its therapeutic effect is due in part to its ability to contract the vessels. It is a vasoconstricting alkaloid used in migraine attacks, when treatment with non-steroidal anti-inflammatory drugs has no effect.
The mechanism of action of ergotamine is complex. The molecule has structural similarities to neurotransmitters such as seratonin, dopamine and adrenaline, and can therefore bind to various receptors and function as an inhibitor. Its use in the treatment of migraines is due to its vasoconstrictor effect of extracerebral intracranial blood vessels through their binding to the 5-HT1B receptor and inhibition of neurotransmitter binding.
Overuse of ergotamine may cause nausea, vomiting (to direct effects on the Central Nervous System in the vomiting centers) , malaise, headache, constriction of peripheral vessels and more severe effects such as ischemia of the extremities.
Ergotamine poisoning is called ergotism.
Ergotamine should not be used in patients with peripheral arterial or venous vascular insufficiency, ischemic heart disease, cerebrovascular disease, systemic infection and hypertension without effective control.
7-12 days after Pre-insemination.
Answer:
1 – Write A To Do List.
2 – Remove Yourself From Distraction.
3 – Take Breaks When Working.
4 – Break Big Tasks Up Into Smaller Chunks.
5 – Find Your Most Productive Times.
Explanation:
These are the five time-management tips which would be the most helpful for me while doing my work. By knowing exactly what it is needed to be done on any given day, you are save your time from wasting. Distraction slows down your work so avoid distraction related things. Take some rest while doing your work in order to refresh your mind. Divide the tasks into small pieces in order to make it easy to be done. Work at that time of the day in which you are more focus and active.
Answer:
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