It can cause changes in the brain and affect certain chemicals in the brain called neurotransmitters. This can lead to changes in mood and behavior such as anger, agression, delusions, heart attacks, strokes, paranoia, blood-borne diseases, tumors in the liver, and kidney failure. It can lead to dependecy bcause if a person has been taking it for so long, they have the strong urge to use it again if they try to stop. I hope this helps.