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Alla [95]
3 years ago
13

Ras is a g-protein that is activated when a growth factor attaches to egfr. its activation results in the replacement of a gdp m

olecule with a gtp molecule, thus allowing a signal transduction pathway to be activated. considering the signal pathway illustrated on this page, what is one potential outcome of a mutation in the ras gene that leads to ras protein hyperactivity. be specific.
Biology
1 answer:
kodGreya [7K]3 years ago
4 0

Answer:

A mutation in Ras protein which will cause hyperactivity will eventually lead to cancer.

Explanation:

Ras protein was first discovered in Rous sarcoma virus (RSV) and it is a proto-oncogene product. In normal conditions, it plays an important role in cellular signalling but in case of gain of function/hyperactivity it gets converted into cellular oncogene. In several types of cancers a point mutation has been reported in Ras protein.

Just like G protein, it is also a GTPase switch protein but unlike G protein which is trimeric, it is monomeric. In the plasma membrane, it is attached with the help of lipids like prenyl or palmitoyl groups. During signal transduction pathway when it gets activated, it downstream activates MAPK pathway and causes gene expression but when it gets hyperactivated it causes over expression of genes leading to cancer.

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Answer:

This disorder is caused by a recessive allele, its inheritance is sex-linked.

Explanation:

The disorder affects boys born to unaffected parents, this means that at least one of them has to be a carrier of the allele which causes the disease. So, if the allele was dominant, it would express in parents and sons. But, in this case, only is expressed in sons, so it can´t be dominant. Moreover, this condition has a sex-linked inheritance because it is always seen in boys and never in girls. This happens due to boys only have an X chromosome, so if they inherit the recessive allele of the disease, they will express it. On the other hand, girls have two X chromosomes, so if they inherit one copy of the recessive allele, they will be carriers and they won't be affected.  

This disorder is never seen in females because they need to have two copies of the recessive allele. However, to have double copy, they should inherit one copy from their mothers and one copy of their fathers, but boys with the allele are affected and they die in early teens without having progeny.  Therefore, a girl can't have a "carrier-father", so they will never have two copies to express the disorder.

8 0
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yanalaym [24]

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B

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romanna [79]

Answer:

2 ATP

Explanation:

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3 years ago
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