Ras is a g-protein that is activated when a growth factor attaches to egfr. its activation results in the replacement of a gdp m
olecule with a gtp molecule, thus allowing a signal transduction pathway to be activated. considering the signal pathway illustrated on this page, what is one potential outcome of a mutation in the ras gene that leads to ras protein hyperactivity. be specific.
A mutation in Ras protein which will cause hyperactivity will eventually lead to cancer.
Explanation:
Ras protein was first discovered in Rous sarcoma virus (RSV) and it is a proto-oncogene product. In normal conditions, it plays an important role in cellular signalling but in case of gain of function/hyperactivity it gets converted into cellular oncogene. In several types of cancers a point mutation has been reported in Ras protein.
Just like G protein, it is also a GTPase switch protein but unlike G protein which is trimeric, it is monomeric. In the plasma membrane, it is attached with the help of lipids like prenyl or palmitoyl groups. During signal transduction pathway when it gets activated, it downstream activates MAPK pathway and causes gene expression but when it gets hyperactivated it causes over expression of genes leading to cancer.
This zone is called as the zone of aeration. It is present between the earth's surface and the water table, and its main constituents are the soil and rocks. The pores which are present in this zone are partly filled with water, and may mix up with air, causing aeration.
In photosynthesis, sunlight is necessary for it allows the plant to synthesize food from the CO2 and water. Without the light, it cannot carry out photosynthesis and create the food to feed itself.
