If you want to be a critical media consumer, you must be aware of all of those things. These factors are very important during the production process in different types of media. They are inter-related, that means they work together to give us, the audience, a determinate product. It's important to have in mind that different interests shape what we consume.
The agenda is the underlying plan: What is going to be done? What are we gonna focus? These objectives are very related to the source of the money, if the financier wants a determinate way of doing things, he will be very influential. Usually the source of the money are related with different organizations which seem their interests affected.
Taking into consideration all this factors you will have a more objective way of consuming media.
Answer: There can be many interpretations to this quote. It could be that one that has never chosen to physically move from somewhere or move in terms of living their lives fully do not notice that they are bound because of themselves or by others. This could also be a literal meaning that those that never got the chance to move at their own will grew to ignore or not notice what physically bounded them.
You'll need to cut the string so you can put the beads on. And the loose knot is so the beads don't fall off as you string them. And of course at the end you need to tie the ends together.