She makes a metaphor comparing the cultural patchwork of the United States to a quilt, in which components coming from many various places are assembled to form a unified new item.
Each little square of the quilt is associated to a group a people who currently live in the US but who came from one of a great many different places all around the world, like native Americans, British, Irish, Chinese, Mexican people, just to name a few, bringing their own colors to the nation.
The answer is that all men are created equal, endowed with certain fundamental rights, that among these are life, liberty and the pursuit of happiness.