Answer and Explanation:
The mechanism of action of statins begins with the inhibition of a protein called HMG-CoA reductase, allowing its substrate to accumulate in the body and promote cholesterol reduction. At that moment, a transporter called OATP (Organic Anion Transporting Polypeptides) takes statins to the epatic tissue where they will be transformed and metabolized until they are eliminated through bile. This elimination is influenced by the P-glycoprotein, which is the main cause of the efflix presented by the bili. This process can get help from other molecules like some protease inhibitors, digoxin and cyclosporine.
Answer:
Many rare and/or endemic species exhibit one or more of the following attributes which make them especially prone to extinction: (1) narrow (and single) geographical range, (2) only one or a few populations, (3) small population size and little genetic variability, (4) over-exploitation by people
Answer:
In most tissues of the body, the response to hypoxia is vasodilation. By widening the blood vessels, the tissue allows greater perfusion. By contrast, in the lungs, the response to hypoxia is vasoconstriction.
Explanation:
Answer:
because California is located on the San Andreas Fault
Explanation:
California is one of the states that have higher seismic activity because it lies on an individual fault known as the San Andreas Fault. Faults are regions where two tectonic plates are moving with respect to one another, thereby they are prone to suffer earthquakes. The San Andreas Fault is a continental fault that extends approximately 800 miles (1,200 kilometers) through the US state. Conversely, earthquakes in North Dakota are uncommon because this state is located in the middle of a tectonic plate. The last earthquake in North Dakota had a magnitude of 3.3 (Richter Scale) and it happened almost 10 years ago (2012), in Williston.
