The French and Indian war tool a lot of lives indeed than the American Revolution. It also involved a lot of countries, but the one that lost the most was France as they were able to lose their foothold in 1760.
If I remember correctly the opium wars resulted in china being figuratively split up by european powers. So, I'd go with 4.
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The Donner Party was a group of American pioneers who migrated to California in a wagon train from the Midwest. Delayed by a series of mishaps, they spent the winter of 1846–47 snowbound in the Sierra Nevada mountain range.
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