According to National Geographic the first enslaved Africans arrived at the British colony of Jamestown, Virginia, in 1619.
Answer:
This will be my last answer for now, but I'm positive the Louisiana Purchase occured between France and the US during Jefferson's Presidency. It was a really good deal for the US, because it was a lot of land for little money. However, envoys under Jefferson negotiated the deal without his direct approval, meaning Jefferson was forced to push for ratification.
Depends on the time period, but a theme was that money changers stimulated trade and help in the development of growing economies as the trade between different regions occur or happen during that time period.