Patrick Henry opposed the U.S. Constitution because he felt it gave to much power to the federal government at the expense of the states. This debate would animate American politics in the subsequent development of the Federalist and Republican parties. The Federalist party favored a strong central government while Republicans favored smaller government.
Because white people are evil, no because frankly they just did not care. They felt that their parents were born here before the Revolutionary war, and that they had a right, Manifest Destiny, to spread however far West they should please. They spread all the way. They regarded the Natives as uncivilized murders and rapists. They were primarily ethnocentric and narcissistic.
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Hope this helps.