The cyclin-dependent kinases (CDKs) are a family of serine or threonine kinases which controls progression through the cell cycle. It is regulated by the subunit cyclins which forms a complex. Any Abnormalities that occur in any of the phases (from the resting state (G0), growth phase (G1), through DNA replication (S) to cell division (M) ) initiate a signal that triggers a cell cycle arrest until the issue is resolved.
CDKs have been shown to regulate other processes, particularly various aspects of transcription, different CDK isoforms have key roles in cancer cell proliferation through loss of regulation of the cell cycle. kinases inhibits several family members, preventing cell-cycle progression, for instance, in response to DNA damage, elimination of the phosphates involves in inhibition by phosphatases of the Cdc25 family is then required for activation of CDKs and cell-cycle progression. Loss of control of the cell cycle leads to the formation of cancer as stated earlier. Therefore, the presence of cyclin-dependent kinases inhibitors might play a role in normal cells becoming cancer cells by preventing cell cycle progression in response to DNA damage which can lead to the formation of cancer cells. It has been stated that the presence of CDK inhibitors is also useful in the treatment of cancerous tumor.
