The tetraspanins Tspan8 and CD151 promote metastasis, exosomes (Exo) being suggested to be important in the cross talk between tumor and host. The contribution of Tspan8 and CD151 to host versus tumor-derived exosome (TEX) activities being not defined, we approached the questions using 3-methylcholanthrene-induced (MCA) tumors from wt, Tspan8ko, CD151ko and Tspan8/CD151 (db)ko mice, implanted into tetraspanin-competent and deficient hosts.
Methods:
Tumor growth and dissemination, hematopoiesis and angiogenesis were surveyed in wild type (wt), Tspan8ko, CD151ko and dbko mice bearing tetraspanin-competent and -deficient MCA tumors. In vitro studies using tumor cells, bone marrow cells (BMC) and endothelial cells (EC) elaborated the mechanism of serum (s)Exo- and TEX-induced target modulation.
Results:
Tumors grew in autochthonous and syngeneic hosts differing in Tspan8- and/or CD151-competence. However, Tspan8ko- and/or CD151ko-tumor cell dissemination and settlement in metastatic organs was significantly reduced in the autochthonous host, and less severely in the wt-host. Impaired wt-MCA tumor dissemination in the ko-host confirmed a contribution of host- and tumor-Tspan8/-CD151 to tumor cell dissemination, delivery of sExo and TEX being severely impaired by a Tspan8ko/CD151ko.
Conclusions:
Tspan8-/CD151-TEX play central roles in tumor progression. Tspan8-/CD151-sExo and TEX contribute by stimulating angiogenesis. Tspan8 and CD151 fulfill these tasks by associating with function-relevant proteins, the additive impact of Tspan8 and CD151 relying on differences in preferred associations. The distinct Tspan8 and CD151 contributions suggest a blockade of TEX-Tspan8 and -CD151 promising for therapeutic intervention.
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The Amish have a genetic trait called polydactyly which is rare among other populations of people. This means that a person can 6 fingers, usually an extra thumb. This kind of evolutionary effect that is exhibited in this specific example is called the Founder effect. This happens when there is a small number of colonizing ancestors.
It is a <span>photosynthetic algae contained in reef building corals underwater</span>
Answer: Synapse connects neurons and neurotransmitters are the chemicals that help in the communication of neurons.
The given statements can be completed as-
The synapse connects the axon of one neuron with the dendrite of another neuron to relay messages.
The cells release chemicals known as neurotransmitters ( such as acetylcholine) into the synaptic gaps to communicate with one another.
Neurotransmitter are the chemical messengers that carry chemical signal to the target neuron where it gets converted into electrical impulses. Synapse is a place or gap between the axon terminal of one neuron and the dendrite of another neuron.
