Answer: Phagocyte receptors that detect PAMPs
Explanation:
TLRs or Toll-like receptors, are a family of proteins that are part of the innate immune system. TLRs are transmembranous and recognize pathogen-associated molecular patterns (PAMPs), which are groups of chemical characteristics common to certain types of pathogens. Patterns detected by TLRs include lipopolysaccharide, a compound found on the surfaces of Gram-negative bacteria, and double-stranded RNA, which is an integral part of the life cycles of many viruses. These PAMPs are generally important for the survival of the pathogen, so they are well preserved. <u>Activation of these receptors induces inflammatory responses in leukocytes of myeloid lineage, signaling via NF-κB, which is a transcription factor that activates pro-inflammatory genes</u>. Activated TLRs also increase the production of co-stimulatory molecules such as CD80, CD86 and CD40. These proteins, expressed on the surface of antigen-presenting cells, are necessary for the activation of T-lymphocytes by dentritic cells and macrophages already showing antigens in their MHC type II molecules (Major Histocompatibility Complex, they participate in the presentation of antigens to T lymphocytes)
<u>In addition, TLR-mediated signaling on antigen-presenting cells (APCs) plays an important role in linking the innate and adaptive immune responses</u>.
Answer:
they all have solid cores of rock, metal, and maybe even ice, but these planets are totally enveloped in thick atmospheres of gas. Hydrogen and helium (the two lightest elements) make up most of the gases in the atmospheres of these planets
Explanation:
internet
Answer:
good conductors of heat, lustrous, malleable and ductile
Explanation:
Metals are solids under normal conditions except for mercury
Answer:
C. a pre-synaptic neuron involved in egg-laying
Explanation:
Serotonin (5-HT) is a neurotransmitter, i.e., a molecule that binds to specific receptors and thus transmits signals from one pre-synaptic neuron to another target cell. In humans, serotonin is involved in many physiological functions including sleep, mood, emotions, appetite, digestion, etc. Moreover, <em>Caenorhabditis elegans</em> is a model organism widely used in neuroscience research in order to understand neuromodulation at the level of individual neurons. In <em>C. elegans,</em> serotonin modifies behavior by regulating neuronal excitability and synaptic efficiency. Moreover, also in <em>C. elegans,</em> it has been shown that serotonin induces egg-laying and also provides a feedback regulatory mechanism by inhibiting the activity of the pre-synaptic neurons that release it. In consequence, in this case, it is expected that serotonin rescues the loss of function of serotonin receptors required for egg-laying by providing a regulatory feedback loop that contributes to serotonin adaptation.
