Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
no blood is not suitable for donation as it will clot too much in the recipient patient and can cause severe problems.
Explanation:
Explanation:
Anaerobic Resistance Training: In this training high intensity, intermittent bouts of exerciese sare done wgich include weight training, interval training, speed, agility, and plyometric drills.
Aerobic Exercise Training: It is physical exercise in which exercises are done from low to high intensity which further depends on the aerobic energy-generating process.
following items would be altered following a lengthy training program are as follwoing:
- Myofibril size and number - Increase with Anaerobic Resistance Training
- Lactic acid processing - Increase with Anaerobic Resistance Training
- Muscular density of blood capillaries - Increase with Anaerobic Resistance Training
- Blood volume and red blood cell count - Increase with Aerobic Exercise Training
- Long-term fatigue resistance - Increase with Aerobic Exercise Training
- Muscle size - Increase with Aerobic Exercise Training
- Mitochondrial density - Increase with Aerobic Exercise Training
Answer:
initially individuals in arranged marriages report more satisfaction in relationships than non-arranged marriages and report less satisfaction over time
Explanation:
