Question

The nurse administers cimetidine to a 75-year-old client diagnosed with a gastric ulcer. the nurse should monitor the client for which adverse reaction?

Answer 1

The nurse administers cimetidine to a 75-year-old client diagnosed with a Gastric ulcer the nurse should monitor the client for the following adverse reactions Headache, Sleepiness, Confusion, Dizziness, Nausea which contribute for the change in Metal status.

• Cimetidine is a H$2$ Receptor Antagonist.
• Gastric partial cells contains receptors for Histamine.

• Histamine is released from the Enterochromaffin cells upon the stimulation from food intake or from Vagus nerve stimulation.
• Thus Histamine released from Enterochromaffin cells binds to H$2$ receptors on the parietal cells and increases the secretion of HCl.

• Cimetidine has totally opposite effect and decreases the secretion of HCl from the parietal cells.
• Not only on gastric cells H$2$ receptors are also present in CNS where they stimulate brain cells.
• The above point justifies the adverse effects of Cimetidine.
• Patients over the age of 50 or those who are severely ill may experience transient confusion while taking H$2$ blockers, particularly cimetidine.

Hence from these points we can conclude that patients who are above 50 years and receiving Cimetidine medication for gastric ulcer should be monitored for the above mentioned adverse reactions.

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