In colder areas if it becomes warmer and hot which is the weather that area does not normally see then animals that live in this area may die or move locations fast because they are not made to live in hot places. Also nature, for example there are some plants and trees that are made to live in colder weather so when it becomes hot they will die and not grow in this area anymore becuase they cannot just get up and walk away as animals can.
Marker/Recognition proteins extend across the cell membrane and serve to identify the cell. The immune system uses these proteins to tell good cells from foreign invaders.