Answer:
Open channels allow an influx of sodium ions into the cytoplasm of the muscle fiber. The sodium influx also sends a message within the muscle fiber to trigger the release of stored calcium ions. The calcium ions diffuse into the muscle fiber.
Explanation:
Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.
We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.
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That students who study make better grades than those who do not.
ANSWER:
D. Chemical energy
Susceptibility refers that they can not grow if drug is present . Antibiotic is effective against the bacteria. Resistant means the bacteria can grow even if the drug is present and this sign is an effective antibiotic.
The antibiotic susceptibility testing are based on measuring the inhibition of growth of bacteria. Average time which requires to obtain result are 18- 24 hours for rapid system.Antibiotic sensitivity test can help in finding that which antibiotic is more effective in treating infection accordingly.
Antimicrobial susceptibility test is very significant bacterial isolates and there goal of testing is to detect possible drug resistance in common pathogen to assure susceptibility to drug of choice for particular infections.
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