The most important and powerful city in the Mesoamerica was the Aztecs Empire capital Tenochtitlan.
Explanation:
Tenochtitlan was the most powerful city in the Mesoamerica. It was Conquered by Hernan Cortez, a Spanish conqueror who aided by an expert translator called "Malinche" was able to walk to the city and conquer it. The city was built on an island in what was then Lake Texcoco.
