Jamestown was situated on a site that was too secluded for agriculture, in fact, the entire island was isolated because it was swamp-like and infested with mosquitoes and the only water came from tidal rivers. This water was unsafe to drink, which could cause health problems such as cholera, typhoid or dysentery. I give credit to @Barnuts
But i agree with this but hope this helps.
I would say
Slightly agreed
The Missouri Compromise (1820) was a compromise that was reached between the North and the South and approved by the country. The 24th state to be admitted was Missouri thanks to Congress (1821). The protracted inter-sectional conflict over the expansion of slavery that eventually resulted in the American Civil War began at that time.
What was the Missouri Compromise?
A law known as the Missouri Compromise of 1820 attempted to alleviate escalating tensions between sections of society over the subject of slavery. The United States enacted the bill, which President James Monroe then signed. Maine was admitted as a free state, and Missouri, a state that permitted slavery, was added to the Union by Congress. The remaining Louisiana Purchase territories north of the 36o 30' line were also exempt from the slavery restriction (the southern border of Missouri). Just over 30 years would pass until the Kansas-Nebraska Act of 1854 abolished the Missouri Compromise. The compromise was declared unconstitutional by the Supreme Court in the Dred Scott decision in 1857, which opened the door for the Civil War.
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The answer is Human
While the other options are always affecting the ecosystems, humans have a greater affect than all of the above
(960) Song Dynasty begins
(1185) Feudal Japan begins
(1600) Tokugawa shogunate established
(1644) Manchu Qing dynasty rules China
(1911) Chinese Revolution
(1937) Japan invades China
(1950) Korean War begins