This is because such a mechanism of regulation prevents the simultaneous addition and removal of glucose monomers, preventing unnecessary reactions. Additionally. the two processes occur in the same location in the sell, thus this regulation makes the net process more efficient. When glycogen phosphorylase is phosphorylated its activity increases and vicevarsa.
Differentiation occurs numerous times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types.