Brodt and Zimbardo found that shy women who were bombarded with loud noise and told that it would leave them with a pounding heart were subsequently no longer so shy when interacting with a handsome male.
a) with a pounding heart; no longer so shy
<u>Explanation:</u>
Shy is an emotion expressing nervousness, being reserved and timidity when communicating or being with some people. Shyness is generally observed in the person who has low self-confidence and inferiority complex.
Brodt and Zimbardo found that when a woman is continuously allowed to face loud noise, initially it may lead to pounding heart and subsequently they get used to it and they will be no longer shy. These scientists also found that when woman is interacting with the handsome male they will never feel shy.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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The object is balanced against standard units of mass
Biotic:
-predator
-competition(relationsip)
abiotic:
-sunlight
-water
Answer:Almost 2/3 of our body store of iron is found in the hemoglobin in our blood
Explanation:
