Answer:
by designing a drug with steric effects on BCR-ABL1
Explanation:
Chronic myeloid leukemia (CML) is a type of cancer that affects the bone marrow and blood cells. CML is characterized by the formation of the Philadelphia chromosome, a product of a reciprocal translocation between chromosomes 9 and 22. As a consequence of this translocation, an oncoprotein tyrosine kinase called BCR-ABL1 is formed. This protein (BCR-ABL1) is responsible for 95% of all CMLs. In this case, it is possible to inhibit BCR-ABL1 (and thus inhibit CML cell proliferation) by using a kinase inhibitor. Kinase inhibitors are drugs that inhibit kinase function by preferentially binding to the inactive conformation of the target enzyme. These proteins are used to treat cancer by blocking a functional site on the kinase, thereby inhibiting its function. Moreover, it is known that steric effects alter the mode and rate by which a drug interacts with a given target. In this case, a small molecule with steric effects on BCR-ABL1, i.e., capable of altering the shape (conformation) and reactivity of BCR-ABL1, might also be used to selectively inhibit BCR-ABL1.
Answer:
The equation is glucose + oxygen carbon dioxide + wafer and energy is produced in the form of ATF
Answer:
The corpse was deposited into the room from somewhere else
Explanation:
<em>The larva could not have spontaneously emerged from the corpse if the blowfly had not somehow perched and laid its egg on it. Since there are no open windows, and perhaps, other openings to the room; the only plausible explanation for the emergence of the blowfly larva would be that the corpse was deposited into the room from somewhere else. From the initial location, the blowfly had perched and laid its egg on the body and the eggs only hatched while in the enclosed room. </em>
