Look at the root, the word isolation can be seen. What does isolation mean? To separate from everyone else. Which answer creates a separation from other countries? B by avoiding contact with other countries
The introduction of the horse to North America by the Spanish changed the lives of Native Americans, because A) Pacific Northwest Indians could hunt buffalo more efficiently. This made it easier for the Native Americans to hunt their buffalo in a more precise and organized manner, due to the way they could round the buffalo up.
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The Federalist Papers were a series of documents, reportedly 85 different ones, that substantiated the ratification of the Constitution. Essentially made to defend it's ratification against the anti-federalists.