Answer:
When we overuse a joint, the bursae become inflamed, resulting in bursitis, a condition in which the bursae lose their function and the movements become painful. Excessive use of some joints can cause bursitis in sports like cycling, tennis, and long-distance running.
Your immune system uses a huge army of defender cells - different types of white blood cell. You make about 1000 million of them every day in your bone marrow. Some of these cells, called macrophages, constantly patrol your body, destroying germs as soon as they enter. This is your 'natural' or inborn immunity. But if an infection begins to take hold, your body fights back with an even more powerful defence of T- and B-cells. They give you acquired immunity, so that the same germ can never make you as ill again.
https://www.thehotline.org/2012/09/11/red-flags-of-abuse/
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Stress. stress really takes it out of you, and can cause a lot of other health problems as well.